精氨酸血管加压素对松果体切除所致未成年雄性大鼠下丘脑5-羟色胺含量及血浆黄体生成素和促卵泡激素浓度变化的逆转作用。

Reversal by arginine-vasotocin of the effects of pinealectomy on the amount of 5-hydroxytryptamine in the hypothalamus and the concentrations of luteinizing hormone and follicle-stimulating hormone in the plasma of immature male rats.

作者信息

Pavel S, Luca N, Calb M, Goldstein R

出版信息

J Endocrinol. 1980 Jan;84(1):159-61. doi: 10.1677/joe.0.0840159.

DOI:10.1677/joe.0.0840159

Abstract

Pinealectomy in immature (25-day-old) male Wistar rats significantly decreased the content of 5-hydroxytryptamine (5-HT) in the hypothalamus and increased concentrations of plasma LH and FSH 3 days after surgery. Extremely small amounts (10(-4) pg) of arginine-vasotocin (AVT) injected into the third ventricle (pineal recess) 5 min after pinealectomy completely prevented the decrease in the hypothalamic content of 5-HT and the increase in the concentration of LH and FSH in the plasma. It is suggested that AVT prevented the increase of plasma levels of LH and FSH after pinealectomy by increasing levels of 5-HT at postsynaptic receptor sites.

摘要

对未成熟（25日龄）雄性Wistar大鼠进行松果体切除术后3天，其下丘脑5-羟色胺（5-HT）含量显著降低，血浆促黄体生成素（LH）和促卵泡生成素（FSH）浓度升高。松果体切除术后5分钟，向第三脑室（松果体隐窝）注射极少量（10(-4)皮克）的精氨酸加压催产素（AVT），可完全防止下丘脑5-HT含量降低以及血浆中LH和FSH浓度升高。提示AVT通过增加突触后受体部位的5-HT水平，防止松果体切除术后血浆LH和FSH水平升高。

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2

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