Shah A C, Nelson K G
J Pharm Sci. 1980 Feb;69(2):210-2. doi: 10.1002/jps.2600690226.
Passive drug transport across a membrane involves the resistances in series offered by the membrane and the liquid layer immediately adjacent to it. The liquid layers generally are referred to as unstirred aqueous diffusion layers, suggesting that solute transport across these layers occurs solely by molecular diffusion. In accord with convective diffusion theory, recent studies showed that the transport from either a dissolving surface or a membrane surface depends not only on molecular diffusion but also on fluid convection inthe liquid adjacent to the membrane. Membrane permeation rates were determined for a series of alkyl p-aminobenzoates, and the results correlated with a model comprised of membrane diffusion and convective diffusion in the adjacent liquid region.
药物跨膜的被动转运涉及膜及其紧邻的液层所提供的串联阻力。这些液层通常被称为未搅拌水扩散层，这表明溶质跨这些层的转运仅通过分子扩散发生。根据对流扩散理论，最近的研究表明，从溶解表面或膜表面的转运不仅取决于分子扩散，还取决于膜附近液体中的流体对流。测定了一系列对氨基苯甲酸烷基酯的膜渗透速率，并将结果与一个由膜扩散和相邻液体区域的对流扩散组成的模型相关联。
