Nelson K G, Shah A C
J Pharm Sci. 1977 Jan;66(1):137-9. doi: 10.1002/jps.2600660141.
Studies were carried out on the permeation rate of butambed through a dimethicone membrane. Under conditions of "aqueous diffusion layer control", the permeation rate was accurately described by a mathematical model based on convective diffusion theory. In accordance with model, the rate of permeation from a saturated donor phase was shown to be equal to the rate of dissolution from a pure solid.
开展了布坦布酯透过二甲基硅油膜的渗透速率研究。在“水相扩散层控制”条件下，基于对流扩散理论的数学模型准确描述了渗透速率。根据该模型，饱和供体相的渗透速率等于纯固体的溶解速率。
