Chin H, Almon R R
J Pharmacol Exp Ther. 1980 Mar;212(3):553-9.
The effects of castration on the extensor digitorum longus, soleus and levator ani muscles of the adult male rat were examined. After castration, no change was observed in the number of sites or the binding affinity of [125I]-monoiodo-alpha-bungarotoxin to the nicotinic cholinergic receptor population of the slow fiber muscle (soleus). The two fast fiber muscles (extensor and levator) showed no change in binding affinity but a significant change in the number of sites. In these two fast fiber muscles, the number of sites begins to increase within the first few days after castration, peaks at 14 days and begins to decline. The results presented in this report demonstrate three major concepts: 1) influences on skeletal muscle mediated by one receptor population can change the characteristics of another receptor population; 2) at least some androgen effects on skeletal muscle are fiber type specific; and 3) the development of extrajunctional receptors is not solely the function of the nerve-muscle relationship.
研究了去势对成年雄性大鼠趾长伸肌、比目鱼肌和肛提肌的影响。去势后，慢肌纤维（比目鱼肌）的烟碱型胆碱能受体群体上，[125I] - 单碘α - 银环蛇毒素的结合位点数量和结合亲和力均未观察到变化。两块快肌纤维（伸肌和提肌）的结合亲和力没有变化，但结合位点数量有显著变化。在这两块快肌纤维中，结合位点数量在去势后的头几天内开始增加，在第14天达到峰值，然后开始下降。本报告中的结果证明了三个主要概念：1）由一种受体群体介导的对骨骼肌的影响可以改变另一种受体群体的特性；2）雄激素对骨骼肌的影响至少有一些是纤维类型特异性的；3）接头外受体的发育不仅仅是神经 - 肌肉关系的功能。
