己烯雌酚暴露组与未暴露组女儿的妊娠经历比较。

A comparison of pregnancy experience in DES-exposed and DES-unexposed daughters.

作者信息

Herbst A L, Hubby M M, Blough R R, Azizi F

出版信息

J Reprod Med. 1980 Feb;24(2):62-9.

Abstract

Reproductive histories were compared for 226 DES-exposed and 203 -unexposed daughters whose mothers participated in a double-blind evaluation 27 years before. Irregular menstruation was slightly more common among the exposed (10%) than among the unexposed (4%). Nineteen of the exposed and only four of the unexposed had primary infertility. Among those at risk, 86% of the unexposed and 67% of the exposed had become pregnant. The reasons for these differences are not known. Comparison of evaluable first pregnancy outcome revealed full-term live birth to be more common among the unexposed (85%) than the exposed (47%). Premature live birth was experienced by 22% of the exposed but only 7% of the unexposed. Nonviable outcomes of stillbirth, neonatal death, miscarriage and ectopic pregnancy occurred in 31% of the exposed and 8% of the unexposed. The difference in pregnancy outcomes between the groups is highly significant. The DES-exposed with transverse cervicovaginal ridges were more likely to experience a nonviable outcome. Overall 82% of the exposed and 93% of the unexposed had at least one live offspring.

摘要

对226名曾接触己烯雌酚（DES）的女儿和203名未接触DES的女儿的生育史进行了比较，这些女儿的母亲在27年前参与了一项双盲评估。月经不规律在接触DES的人群中（10%）比未接触者（4%）略为常见。接触DES的人群中有19人原发性不孕，而未接触者中只有4人。在有生育风险的人群中，未接触者的怀孕率为86%，接触者为67%。这些差异的原因尚不清楚。对可评估的首次妊娠结局进行比较发现，足月活产在未接触者中（85%）比接触者中（47%）更为常见。早产活产在接触者中占22%，而未接触者中仅占7%。死产、新生儿死亡、流产和异位妊娠等不良妊娠结局在接触者中占31%，在未接触者中占8%。两组之间妊娠结局的差异非常显著。有横向宫颈阴道嵴的接触DES者更有可能出现不良妊娠结局。总体而言，82%的接触者和93%的未接触者至少有一个存活后代。