Noyek A M, Pritzker K P, Greyson N D, Blackstein M, Chapnik J S, Shapiro B J
J Otolaryngol. 1980 Feb;9(1):90-6.
Warthin's tumor of the parotid gland is an unusual tumor for which a number of theories of pathogenesis have been advanced through the years, ranging from a branchiogenic origin to an embryonic lymph node origin to true neoplasia from parotid epithelial duct cells. Recently Allegra has suggested that Warthin's tumor may be a hypersensitivity disease. Presented here are two unique cases of Warthin's tumor, having both a familial relationship (synchronous occurrence in mother and son) and the association with cystic oncocytic metaplasia of the larynx. Observations lead to the conclusion that the lesion is primarily metaplastic, not neoplastic, with a secondary lymphoid reaction of the delayed hypersensitivity type.
腮腺沃辛瘤是一种不常见的肿瘤，多年来人们提出了许多关于其发病机制的理论，从鳃源性起源到胚胎淋巴结起源，再到腮腺上皮导管细胞的真性肿瘤形成。最近，阿莱格拉提出沃辛瘤可能是一种超敏反应性疾病。本文介绍了两例独特的沃辛瘤病例，它们既有家族关系（母亲和儿子同时发病），又与喉的囊性嗜酸性细胞化生有关。观察结果得出结论，该病变主要是化生，而非肿瘤，伴有迟发型超敏反应类型的继发性淋巴样反应。
