Corenblum B, LeBlanc F E, Watanabe M
JAMA. 1980 Apr 11;243(14):1456-7.
A patient with acromegaly was found to have a discrete adenoma of the pharyngeal pituitary lodged within the sphenoid sinus. Removal of this adenoma, believed to be complete, did not normalize the growth hormone secretion. At the time of surgery, inspection and biopsy of the pituitary gland failed to disclose the presence of any identifiable intrasellar adenoma; one year later, however, definite radiological changes indicated the presence of an intrasellar mass. The underlying pathophysiology in this patient may have been due to diffuse hyperplasia of hypersecreting nonsuppressible somatotrophs, with adenoma formation secondary to the hyperplasia.
一名肢端肥大症患者被发现蝶窦内有一个孤立的咽垂体腺瘤。切除该腺瘤（认为已完整切除）后，生长激素分泌并未恢复正常。手术时，对垂体进行检查和活检未发现任何可识别的鞍内腺瘤；然而，一年后，明确的放射学改变表明存在鞍内肿块。该患者潜在的病理生理机制可能是分泌过多且不可抑制的生长激素细胞弥漫性增生，腺瘤形成继发于这种增生。
