口服避孕药对单核细胞胆固醇酯水解酶活性的影响。

The effect of oral contraceptives on mononuclear cell cholesteryl ester hydrolase activity.

作者信息

Hagemenas F C, Yatsu F M, Manaugh L C

出版信息

Lipids. 1980 Jan;15(1):39-44. doi: 10.1007/BF02534116.

Abstract

The influence of sex steroids on mononuclear cell cholesteryl ester hydrolase (CEH) activity in premenopausal women and women on combined estrogen-progestin oral contraceptives has been studied. In addition, plasma and mononuclear cell cholesterol and esters were measured along with plasma estrogen and progesterone levels. Mononuclear cell CEH activity in control women is highest on Day 20 of their menstrual cycle. The control women had significantly higher CEH activities than women on oral contraceptives. Plasma esters were higher in the oral contraceptive group. However, in mononuclear cells, free cholesterol but not cholesteryl esters were higher in women on oral contraceptives.

摘要

已研究了性类固醇对绝经前女性及服用雌激素 - 孕激素联合口服避孕药女性单核细胞胆固醇酯水解酶（CEH）活性的影响。此外，还测量了血浆和单核细胞中的胆固醇及酯类，以及血浆雌激素和孕激素水平。对照女性的单核细胞CEH活性在月经周期的第20天最高。对照女性的CEH活性显著高于服用口服避孕药的女性。口服避孕药组的血浆酯类较高。然而，在单核细胞中，服用口服避孕药的女性游离胆固醇较高，而胆固醇酯不高。