Graham R L, Gambrell R D
Obstet Gynecol. 1980 Mar;55(3):395-7. doi: 10.1097/00006250-198003000-00028.
Danazol is a synthetic steroid with antigonadotropic properties useful in treating endometriosis, especially in young infertile women. Prior to its availability for clinical use in September 1976, thyroid function studies other than thyroid-stimulating hormone (TSH), which was normal, had not been reported. Soon after danazol began to be used in the infertility clinic to treat documented endometriosis, it was observed that changes occurred in thyroid function studies. While no patients manifested clinical evidence of hypothyroidism, all 8 patients receiving 800 mg of danazol daily for 1 to 5 months had laboratory evidence of decreased thyroid function. The triiodothyronine (T3) uptake was elevated and the total serum thyroxine (T4) was decreased. The finding that TSH and the free thyroid index (FTI) were normal confirmed that these patients were euthyroid during danazol therapy. The abnormality of thyroid function tests is believed to reflect an androgen-like reduction in thyroxine-binding protein rather than a true decrease in thyroid function or interference with the pituitary-thyroid axis.
达那唑是一种具有抗促性腺激素特性的合成类固醇，可用于治疗子宫内膜异位症，尤其适用于年轻的不孕女性。在1976年9月其可供临床使用之前，除促甲状腺激素（TSH）正常外，未报告其他甲状腺功能研究。达那唑开始用于不孕诊所治疗确诊的子宫内膜异位症后不久，就观察到甲状腺功能研究出现了变化。虽然没有患者表现出甲状腺功能减退的临床证据，但所有8例每天接受800毫克达那唑治疗1至5个月的患者都有甲状腺功能降低的实验室证据。三碘甲状腺原氨酸（T3）摄取升高，血清总甲状腺素（T4）降低。促甲状腺激素和游离甲状腺指数（FTI）正常这一发现证实了这些患者在达那唑治疗期间甲状腺功能正常。甲状腺功能测试的异常被认为反映了甲状腺素结合蛋白的雄激素样减少，而不是甲状腺功能的真正降低或对垂体-甲状腺轴的干扰。
