Rubin J, Decker D A, Ahmann D L, Eagan R T, Ingle J N, Hahn R G
Oncology. 1980;37(3):149-51. doi: 10.1159/000225424.
A phase II study utilizing VP-16 and adriamycin in a randomized fashion tested the concept of synchronization of the drugs in treatment of metastatic breast cancer. Although there was a trend in median survival following the synchronized schedule, there was no significant difference in survival or progression-free intervals. The concept of synchronization was not established.
一项利用依托泊苷和顺阿霉素进行随机分组的II期研究，检验了药物同步应用于转移性乳腺癌治疗的概念。尽管同步给药方案后的中位生存期有上升趋势，但在生存期或无进展间期方面并无显著差异。同步治疗的概念未得到证实。
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