由四氯化碳（CCl4）或氯化亚铁（FeCl2）诱导的微粒体脂质过氧化导致的红细胞溶解。

Lysis of erythrocytes as a result of microsomal lipid peroxidation induced by CCl4 or FeCl2.

作者信息

Schulze R M, Kappus H

出版信息

Res Commun Chem Pathol Pharmacol. 1980 Jan;27(1):129-37.

Abstract

Rat liver microsomal lipid peroxidation as measured by malondialdehyde formation induced by the NADPH-dependent metabolism of CCl4 led to a concomitant lysis of erythrocytes added to the incubation mixture. The hemolytic process was closely related to the rate of malondialdehyde formation. The time elapsed for initiation and completion of hemolysis and the rate of malondialdehyde formation correlated well with the concentration of CCl4 used. Similar results were obtained during FeCl2-induced microsomal lipid peroxidation and hemolysis. The occurrence of products with hemolytic activity during CCl4-induced microsomal lipid peroxidation is discussed in relation to the hepatotoxicity of CCl4.

摘要

通过四氯化碳的NADPH依赖性代谢诱导产生丙二醛来测定大鼠肝微粒体脂质过氧化，这导致添加到孵育混合物中的红细胞随之发生裂解。溶血过程与丙二醛的形成速率密切相关。溶血开始和完成所经过的时间以及丙二醛的形成速率与所用四氯化碳的浓度密切相关。在氯化亚铁诱导的微粒体脂质过氧化和溶血过程中也获得了类似的结果。本文讨论了四氯化碳诱导微粒体脂质过氧化过程中具有溶血活性的产物的出现与四氯化碳肝毒性的关系。