Eeckhout C, De Wever I, Peeters T, Hellemans J, Vantrappen G
Am J Physiol. 1978 Dec;235(6):E666-9. doi: 10.1152/ajpendo.1978.235.6.E666.
The duration of the disruption of the interdigestive migrating myoelectric complex (MMC) by various test meals in dogs was correlated with changes in serum gastrin and insulin levels. The test meals consisted of milk protein, sucrose, arachis oil and medium chain triglycerides (MCT). Intravenous infusions of glucose 20% were also used. Electrical activity of the small intestine was registered by means of electrodes implanted over the entire length of the gut. Hormones were assayed by radioimmunoassay techniques. The insulin level rose significantly after both the glucose infusion and the sucrose meal. The rise was small after the milk protein meal and nothing after arachis oil and MCT. Gastrin level was not changed by arachis oil or MCT and rose slightly after sucrose and milk protein. The MMC was not disrupted by glucose infusions, but was disrupted for 5--7 h by archis oil and for 6--12 h by MCT. We conclude that in dogs neither gastrin nor insulin have an important role in the mechanism of disruption of the MMC after feeding.
不同测试餐对犬消化间期移行性肌电复合波（MMC）的干扰持续时间，与血清胃泌素和胰岛素水平的变化相关。测试餐包括乳蛋白、蔗糖、花生油和中链甘油三酯（MCT）。还使用了20%葡萄糖的静脉输注。通过植入于肠道全长的电极记录小肠的电活动。采用放射免疫分析技术测定激素。葡萄糖输注和蔗糖餐之后，胰岛素水平显著升高。乳蛋白餐之后升高幅度较小，花生油和MCT餐之后则无变化。花生油或MCT未改变胃泌素水平，蔗糖和乳蛋白餐之后胃泌素水平略有升高。葡萄糖输注未干扰MMC，但花生油干扰MMC达5 - 7小时，MCT干扰达6 - 12小时。我们得出结论，在犬中，进食后胃泌素和胰岛素在MMC干扰机制中均不起重要作用。
