Fedorov V D, Brusilovskiĭ M I, Eropkin P V, Odariuk T S, Maksimova L V
Vopr Onkol. 1980;26(2):25-30.
It was shown that during radical operations, performed for local spread of rectal cancer (T3--T4, P3--P4), in most patients tumor cells identical to the primary tumor are found in the thoracic duct lymph. To the end of prophylaxis of intraoperative lymphogenic dissemination of tumor cells 71 patients with rectal cancer, spread locally, were subjected preoperatively to endolymphatic infusion of 10% dibunol solution in iodolipol or chromolymphotrast. The preparation was found to be completely deposited in the lymphatic system and to block the routes of lymphogenic dissemination of tumor cells. A considerably reduced number of the postoperative metastases and recurrence of rectal cancer was noted in patients, subjected to radical operations following endolymphatic infusion of oil dibunol solution.
结果表明，在因直肠癌局部扩散（T3 - T4，P3 - P4）而进行的根治性手术过程中，多数患者的胸导管淋巴液中可发现与原发肿瘤相同的肿瘤细胞。为预防术中肿瘤细胞的淋巴源性播散，71例局部扩散的直肠癌患者术前接受了碘化油或铬淋巴造影剂中10%双丁酚溶液的内淋巴注入。结果发现该制剂完全沉积于淋巴系统并阻断肿瘤细胞的淋巴源性播散途径。在接受油双丁酚溶液内淋巴注入后进行根治性手术的患者中，术后直肠癌转移和复发的数量显著减少。
