Franconi F, Manghi N, Giotti A, Martini F, Dini G
Acta Pharmacol Toxicol (Copenh). 1980 Feb;46(2):98-104. doi: 10.1111/j.1600-0773.1980.tb02427.x.
Sodium selenite showed a negative inotropic effect on isolated and perfused guinea-pig heart. The effect was dose-dependent and was not reversed by a higher calcium concentration or by washing. Electronic microscopy revealed mitochondrial alterations. Pyruvate and lactate 2 X 10(-3)M seemed able to reverse the negative inotropic effect and mitochondrial alterations induced by sodium selenite.
亚硒酸钠对离体灌流的豚鼠心脏呈现负性肌力作用。该作用呈剂量依赖性，且较高钙浓度或冲洗均不能使其逆转。电子显微镜检查显示线粒体有改变。2×10⁻³M的丙酮酸和乳酸似乎能够逆转亚硒酸钠所致的负性肌力作用和线粒体改变。
