Cox R H, Bagshaw R J
Am J Physiol. 1980 Feb;238(2):H182-90. doi: 10.1152/ajpheart.1980.238.2.H182.
Studies were conducted in halothane-anesthetized dogs to evaluate the interaction of mean and pulsatile components of carotid sinus perfusion pressure on the control of regional pressure-flow relations. Pressure and flow were measured simultaneously in the ascending aorta, celiac, mesenteric, renal, and iliac arteries. The carotid sinuses were bilaterally isolated and perfused under controlled conditions. Mean (CSP) and pulsatile components (CSPP) of carotid sinus pressure were varied systemically. Values of mean aortic pressure (AP) at the operating point (AP = CSP) decreased with increasing CSPP (127 +/- 5 at CSPP = 0 to 103 +/- 5 at CSPP = 60). Reflex gains at the operating point also decreased with increasing CSPP (-1.35 +/- 0.16 for CSPP = 0 to -0.92 +/- 0.18 for CSPP = 60). Changes in cardiac output and peripheral resistance nonuniformly contributed to these responses, with the former predominating at low CSPP and the later at high CSPP. Operating-point values of regional resistance generally decreased with increasing CSPP but to different degrees in the various beds. With increasing CSPP amplitude, regional resistance sensitivity at the operating point (i.e., slope) increased in the celiac and decreased in the mesenteric, renal, and iliac vascular beds. Separate changes in mean and pulsatile components of carotid sinus pressure about the normal operating point produce quantitatively similar changes in systemic hemodynamic variables.
在氟烷麻醉的犬身上进行了研究，以评估颈动脉窦灌注压的均值和搏动成分对局部压力-血流关系控制的相互作用。同时测量升主动脉、腹腔动脉、肠系膜动脉、肾动脉和髂动脉的压力和血流。双侧分离颈动脉窦并在受控条件下进行灌注。系统性地改变颈动脉窦压力的均值（CSP）和搏动成分（CSPP）。工作点处的平均主动脉压（AP）值（AP = CSP）随着CSPP的增加而降低（CSPP = 0时为127±5，CSPP = 60时为103±5）。工作点处的反射增益也随着CSPP的增加而降低（CSPP = 0时为-1.35±0.16，CSPP = 60时为-0.92±0.18）。心输出量和外周阻力的变化对这些反应的贡献不一致，前者在低CSPP时占主导，后者在高CSPP时占主导。局部阻力的工作点值通常随着CSPP的增加而降低，但在不同血管床中降低程度不同。随着CSPP幅度的增加，腹腔血管床中工作点处的局部阻力敏感性（即斜率）增加，而在肠系膜、肾和髂血管床中降低。围绕正常工作点分别改变颈动脉窦压力的均值和搏动成分，会使全身血流动力学变量产生定量相似的变化。
