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估计遗传相关性。

Estimating genetic correlations.

作者信息

Smith C A

出版信息

Ann Hum Genet. 1980 Jan;43(3):265-84. doi: 10.1111/j.1469-1809.1980.tb01560.x.

Abstract

A method is proposed for simultaneous estimation of genetical variance and covariance components for quantitative characters and hence correlations and cross-correlations between relatives. It proceeds by successive approximations, which are not difficult to compute. Judging by examples, they appear to converge rapidly in practice. When distributions are normal and homoscedastic, the method gives the maximum-likelihood estimates and their error variances and covariances. It can be readily modified to take into account assumptions such as that means and variances are equal in fathers and sons. But the amount of calculations required goes up very rapidly with the number of characters and relatives considered stimultaneously.

摘要

提出了一种同时估计数量性状的遗传方差和协方差分量的方法,从而估计亲属之间的相关性和交叉相关性。该方法通过逐次逼近进行,计算并不困难。从实例来看,在实际应用中它们似乎收敛得很快。当分布为正态且同方差时,该方法给出最大似然估计及其误差方差和协方差。它可以很容易地修改以考虑诸如父子均值和方差相等之类的假设。但是,随着同时考虑的性状和亲属数量的增加,所需的计算量会迅速增加。

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