[Effect of supplementary carbohydrate and nitrogen sources on metabolite concentration in the mycelium of Penicillium nigricans Thom].

The effect of additional sources of carbon (glucose) and nitrogen (NaNO3) on the dynamics of the levels of glucose-6-phosphate (G-6-P), phosphoenolpyruvate (PEP) and pyruvate in the mycelium of the productive strain of P. nigricans synthesizing griseofulvin was studied. It was found that the PEP level was characterized by stability, while the levels of G-6-P and pyruvate depended on the mycelium age at the time of the source addition, the addition type, i.e. addition of a source alone or a mixture of sources and the way of addition (single or divided).