Sheehan T J
Arch Intern Med. 1980 Apr;140(4):472-4.
Since two thirds of the studies appearing in the best medical journals contain unwarranted conclusions, it is important for the physician to be aware of pitfalls. Two common errors are committed; the first consists of confusing statistical significance with medical significance, and the second deals with drawing substantive conclusions from an accepted null hypothesis. In common parlance, significance pertains to importance and meaningfulness, whereas statistical significance specifies the probability that an observed effect could have been produced by chance variation. The null hypothesis is the hypothesis of no experimental effect or correlation. It can be accepted or rejected. The fact that a null hypothesis is accepted does not prove that it is true, ie, that there is no experimental effect or correlation.
由于发表在顶尖医学期刊上的研究中有三分之二包含不合理的结论,因此医生了解其中的陷阱很重要。常见的错误有两个;第一个错误是将统计学显著性与医学显著性混淆,第二个错误是从被接受的零假设中得出实质性结论。通俗地说,显著性涉及重要性和意义,而统计学显著性则指定了观察到的效应可能由随机变异产生的概率。零假设是指没有实验效应或相关性的假设。它可以被接受或拒绝。零假设被接受这一事实并不证明它是真的,即不存在实验效应或相关性。