Burks L C, Aisner J, Fortner C L, Wiernik P H
Arch Intern Med. 1980 Apr;140(4):483-4.
Meperidine hydrochloride was evaluated in a prospectively randomized double-blind study for its effectiveness in stopping shaking chills occurring with amphotericin B infusions. Seven patients were randomized on multiple occasions for a total of 19 reactions. In the meperidine group, nine of nine reactions stopped within 30 minutes of the administration of meperidine, with a mean cessation time of 10.8 minutes. The placebo group had a mean time of 37.4 minutes to cessation of reactions with three of ten reactions subsiding spontaneously. The mean dose of meperidine hydrochloride for cessation of reaction was 45 mg. The comparisons between meperidine and placebo for cessation of reaction within 30 minutes and the mean time to cessation of reaction were significantly different. Side effects with meperidine were minimal and less severe than the shaking chills and fever seen with amphotericin B infusions. Meperidine can eliminate these reactions more effectively and more rapidly than simply discontinuing the amphotericin B.
在一项前瞻性随机双盲研究中，对盐酸哌替啶用于停止两性霉素B输注时出现的寒战的有效性进行了评估。7名患者多次随机分组，共发生19次反应。在哌替啶组中，9次反应中有9次在给予哌替啶后30分钟内停止，平均停止时间为10.8分钟。安慰剂组反应停止的平均时间为37.4分钟，10次反应中有3次自发消退。停止反应的盐酸哌替啶平均剂量为45毫克。哌替啶与安慰剂在30分钟内反应停止情况及反应停止平均时间的比较有显著差异。哌替啶的副作用极小，且比两性霉素B输注时出现的寒战和发热症状轻。与单纯停用两性霉素B相比，哌替啶能更有效、更迅速地消除这些反应。
