Ayus J C, Olivero J J, Adrogué H J
Arch Intern Med. 1980 Apr;140(4):513-5.
Hemodialysis with a low-bicarbonate dialysate was used in four patients for the simultaneous treatment of acute renal failure and fluid overload associated with alkalemia. All patients had a mixed acid-base disorder, namely respiratory alkalosis superimposed on metabolic alkalosis. Correction of alkalemia and azotemia was accomplished with low-bicarbonate dialysis without signs of hemodynamic deterioration. This successful experience, coupled with the reported side effects of acetate-containing dialysate, would suggest the use of a low-bicarbonate dialysate as a recommended therapy of renal failure associated with alkalemia.
四名患者采用低碳酸氢盐透析液进行血液透析，以同时治疗急性肾衰竭和与碱血症相关的液体超负荷。所有患者均存在混合性酸碱紊乱，即呼吸性碱中毒叠加代谢性碱中毒。通过低碳酸氢盐透析实现了碱血症和氮质血症的纠正，且无血流动力学恶化迹象。这一成功经验，再加上含醋酸盐透析液已报道的副作用，表明低碳酸氢盐透析液可作为与碱血症相关的肾衰竭的推荐治疗方法。
