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白卡诺鸽饮食加剧颈动脉粥样硬化形成的时间进程。

Time course of diet-exacerbated carotid artery atherogenesis in the White Carneau pigeon.

作者信息

Hrapchak B B, Bond M G, Wood L L, Hostetler J R

出版信息

Atherosclerosis. 1980 Mar;35(3):243-58. doi: 10.1016/0021-9150(80)90123-9.

DOI:10.1016/0021-9150(80)90123-9
PMID:7362698
Abstract

The carotid arteries of White Carneau pigeons fed an atherogenic diet developed fatty streaks, proliferative and atheromatous lesions. The carotid bifurcation had accelerated lesion development when compared to either the proximal internal carotid or the dorsal carotid artery. After 4 weeks of being fed an atherogenic diet, the bifurcation region of all birds showed some lesion involvement. Lesions at the bifurcation initially involved the medial and lateral walls; flow dividers became involved slightly later, with the anterior flow divider consistently developing thicker lesions than the posterior flow divider. Lesions progressed in terms of length of circumference, mean thickness, cross-sectional area, and percent lumen stenosis as the time fed the atherogenic diet increased.20

摘要

喂食致动脉粥样化饮食的白卡诺鸽的颈动脉出现了脂肪条纹、增生性病变和动脉粥样硬化病变。与颈内动脉近端或颈背动脉相比,颈动脉分叉处的病变发展加速。在喂食致动脉粥样化饮食4周后,所有鸟类的分叉区域都出现了一些病变。分叉处的病变最初累及内侧壁和外侧壁;分流器稍后才受累,前分流器的病变始终比后分流器更厚。随着喂食致动脉粥样化饮食时间的增加,病变在圆周长度、平均厚度、横截面积和管腔狭窄百分比方面都有所进展。

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