磺吡酮对人体血小板聚集、5-羟色胺释放及体外黏附的影响：与萘普生的比较。
Effect of sulphinpyrazone on human platelet aggregation, 5-hydroxytryptamine release and adhesion ex vivo: comparison with naproxen.
作者信息
Nunn B, James F J
出版信息
Br J Clin Pharmacol. 1980 Mar;9(3):239-45. doi: 10.1111/j.1365-2125.1980.tb04833.x.
Abstract
1 The effects of single doses of naproxen and sulphinpyrazone and of 4 and 8 days treatment with sulphinpyrazone on human platelet responsiveness were compared. 2 A single dose of sulphinpyrazone had no effect whereas a single dose of naproxen caused a five-fold depression in responsiveness to collagen. 3 Repeated administration of sulphinpyrazone led to a weak and equivocal inhibitory effect on collagen-induced aggregation, second phase aggregation in response to ADP and adhesion to collagen. There was no effect on ADP-induced first phase aggregation, adrenaline-induced second phase aggregation or platelet retention in glass bead columns. 4 It is concluded that the anti-aggregant activity of sulphinpyrazone is too weak to be a major factor in its reported effect on the incidence of cardiac death.
摘要
- 比较了单剂量萘普生和磺吡酮以及磺吡酮4天和8天治疗对人血小板反应性的影响。2. 单剂量磺吡酮无作用，而单剂量萘普生使对胶原的反应性降低了五倍。3. 重复给予磺吡酮对胶原诱导的聚集、对ADP的第二相聚集以及对胶原的黏附产生微弱且不明确的抑制作用。对ADP诱导的第一相聚集、肾上腺素诱导的第二相聚集或玻璃珠柱中的血小板滞留无作用。4. 得出结论：磺吡酮的抗聚集活性太弱，不可能是其对心脏死亡发生率报道效应的主要因素。
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Effect of sulphinpyrazone on human platelet aggregation, 5-hydroxytryptamine release and adhesion ex vivo: comparison with naproxen.磺吡酮对人体血小板聚集、5-羟色胺释放及体外黏附的影响：与萘普生的比较。
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