Graham J J, Harding P E, Hoare L L, Thomas D W, Wise P H
Br J Surg. 1980 Feb;67(2):115-8. doi: 10.1002/bjs.1800670213.
The incidental finding of hypercalcaemia during multi-channel screening was the initiating event in 33 (45 per cent) of 79 consecutive cases of surgically treated primary hyperparathyroidism. This subgroup was asymptomatic as defined. Although significant biochemical differences existed between symptomatic and asymptomatic cases, a range of metabolic indices of bone turnover fell postoperatively in almost all asymptomatic subjects, although initially abnormal in only 35 per cent. Achievement of normocalcaemia was significantly surgeon-dependent.
在79例接受手术治疗的原发性甲状旁腺功能亢进连续病例中，33例（45%）的多通道筛查时偶然发现高钙血症是起始事件。这个亚组按定义是无症状的。虽然有症状和无症状病例之间存在显著的生化差异，但几乎所有无症状受试者术后骨转换的一系列代谢指标均下降，尽管最初只有35%异常。血钙正常的实现显著依赖于外科医生。
