Mitchell D M, Mitchell D N, Collins J V, Emerson C J
Br Med J. 1980 Mar 8;280(6215):679-81. doi: 10.1136/bmj.280.6215.679.
Sarcoidosis was ultimately diagnosed in a consecutive series of 79 patients, of whom 24 presented with unusual features. Histological support for this diagnosis was obtained in 37 out of 42 patients who underwent transbronchial biopsy; epithelioid and giant-cell granulomas were also found on biopsy of the bronchial mucosa in 17 out of 22 patients. Kveim tests were completed in 44 patients: results were positive in 19, equivocal in 11, and negative in 14. In 16 patients histological support was obtained on biopsy of various other tissues. The clinical presentation of the disease and the degree of histological support provided by the various procedures used in reaching a diagnosis of sarcoidosis varied considerably. Transbronchial biopsy of the lung is a useful advance in diagnosing sarcoidosis and provided a higher diagnostic yield than any other method.
最终，在连续的79例患者中确诊为结节病，其中24例具有不寻常的特征。42例接受经支气管活检的患者中有37例获得了该诊断的组织学支持；22例患者中有17例在支气管黏膜活检中也发现了上皮样和巨细胞肉芽肿。44例患者完成了克维姆试验：19例结果为阳性，11例为可疑，14例为阴性。16例患者在其他各种组织的活检中获得了组织学支持。该疾病的临床表现以及在结节病诊断中使用的各种程序所提供的组织学支持程度差异很大。经支气管肺活检是结节病诊断中的一项有用进展，其诊断阳性率高于任何其他方法。
