Mitchell S J, Ranck J B
Brain Res. 1980 May 5;189(1):49-66. doi: 10.1016/0006-8993(80)90006-2.
A regular slow wave theta rhythm can be recorded in the medial entorhinal cortex (MEC) of freely moving rats during voluntary behaviors and paradoxical sleep. Electrode penetrations normal to the cortical layers proceeding from the deeper to the more superficial layers reveal a continuous theta rhythm in layers IV-III (deep MEC theta rhythm) with an amplitude maximum in layer III, a null between the outer one-third of layer III and the inner one-half of layer I, and a continuous phase-reversed theta rhythm in layers II-I (superficial MEC theta rhythm) with an amplitude maximum there. Deep MEC theta rhythm is similar in phase and wave shape to CA1 theta rhythm; superficial MEC theta rhythm is similar in phase to DG theta rhythm. Laminar profiles throughout MEC show that the theta rhythm is generated there; it is not volume conducted from hippocampus.
在自由活动的大鼠进行自主行为和异相睡眠期间，可在内侧内嗅皮质（MEC）记录到规则的慢波θ节律。垂直于皮质层从深层到浅层的电极穿刺显示，IV-III层（深层MEC θ节律）存在连续的θ节律，在III层振幅最大，在III层外三分之一与I层内二分之一之间为零，而II-I层（浅层MEC θ节律）存在连续的相位反转θ节律，在该层振幅最大。深层MEC θ节律在相位和波形上与CA1 θ节律相似；浅层MEC θ节律在相位上与DG θ节律相似。整个MEC的层状分布表明，θ节律是在那里产生的；它不是从海马体容积传导而来的。
