Manzo L, Gregotti C, Richelmi P, Di Nucci A, Bertè F
Chemotherapy. 1980;26(3):164-70. doi: 10.1159/000237900.
The administration of phenobarbitone to the rat (8 mg/100 g BW) once daily for 3 days significantly decreased the serum and tissue levels of erythromycin administered intraperitoneally (5 mg/100 g BW). Furthermore, phenobarbitone stimulated the hepatic microsomal N-demethylation of erythromycin and increased the biliary concentration and the biliary excretion rate of the unmetabolized antibiotic. These effects were accompanied by augmented liver mass and bile flow. The possibility is discussed that erythromycin concentrates in the bile through a specialized hepatic drug transport system, activated by phenobarbitone.
连续3天每天给大鼠腹腔注射苯巴比妥（8毫克/100克体重），显著降低了腹腔注射红霉素（5毫克/100克体重）后的血清和组织水平。此外，苯巴比妥刺激了红霉素的肝微粒体N-去甲基化，增加了未代谢抗生素的胆汁浓度和胆汁排泄率。这些作用伴随着肝脏质量和胆汁流量的增加。文中讨论了一种可能性，即红霉素通过苯巴比妥激活的特殊肝脏药物转运系统在胆汁中浓缩。
