Mathey D, Montz R, Hanrath P, Kuck K H, Bleifeld W
Dtsch Med Wochenschr. 1980 Apr 11;105(15):509-15. doi: 10.1055/s-2008-1070697.
For evaluation of coronary artery spasm 201thallium sequential scintigraphy of the myocardium after ergotamine provocation was performed in 10 patients with recurrent angina pectoris at rest and normal exercise ECG. In 9 out of the 10 patients ergotamine administration in the same dosage was repeated during the coronary angiography. A reversible defect in the 201thallium scintigram representative of regional myocardial ischaemia developed in 9 patients after ergotamine. Only in 4 out of the 9 patients angina pectoris and ST elevation were present at the same time. In all cases coronary spasm after ergotamine was demonstrable in the coronary angiogram; in the 4 patients with ergotamine-induced Prinzmetal angina pectoris it consisted of complete vascular occlusion, in the asymptomatic patients of incomplete vascular narrowing of a higher degree. In all cases the spasm could be relieved by ergotamine antidotes within a few minutes.
为评估冠状动脉痉挛,对10例静息时反复发作心绞痛且运动心电图正常的患者进行了麦角胺激发试验后201铊心肌序贯闪烁显像。10例患者中有9例在冠状动脉造影期间以相同剂量重复给予麦角胺。麦角胺给药后,9例患者的201铊闪烁显像出现代表局部心肌缺血的可逆性缺损。9例患者中只有4例同时出现心绞痛和ST段抬高。在所有病例中,冠状动脉造影均显示麦角胺激发后出现冠状动脉痉挛;在4例麦角胺诱发的变异型心绞痛患者中,痉挛表现为血管完全闭塞,在无症状患者中则为程度较高的血管不完全狭窄。在所有病例中,痉挛均可在几分钟内被麦角胺解毒剂缓解。