Fischer R, Berg E, Dorr S
Dtsch Med Wochenschr. 1980 Apr 18;105(16):551-6. doi: 10.1055/s-2008-1070704.
Mesangioproliferative glomerulonephritis of varying severity was found by renal biopsy in 86.2% among 130 patients with asymptomatic haematuria. 3.2% had benign nephrosclerosis, 3.2% had benign nephrosclerosis, 1.6% had interstitial nephritis and one patient showed a previously undiagnosed perimembranous glomerulonephritis. Normal renal parenchyma was observed in only 6.9% of cases. Iummunohistological findings were positive in 25.7% of investigated cases. The majority were IgA deposits combined with IgG and C3 complement. The intensity of haematuria is not correlated with the type and severity of histological changes. "Physiological" haematuria (erythrocytes less than 7/ml) which is usually considered normal must be re-evaluated as a consequence of these histological findings. After exclusion of urological or extrarenal disease only histological investigation of the kidneys will bring the final diagnosis. Repeated radiographical or urological investigations can thus be avoided. The risks of percutaneous renal biopsy under fluoroscopic or sonographic control are decidedly less than the information gained from histological evaluation. The different histological findings indicate that isolated haematuria should be considered only as a symptom and not as a uniform disease indicating focal nephritis.
在130例无症状血尿患者中,肾活检发现86.2%存在不同严重程度的系膜增生性肾小球肾炎。3.2%有良性肾硬化,1.6%有间质性肾炎,1例显示为先前未诊断出的膜性肾小球肾炎。仅6.9%的病例观察到正常肾实质。免疫组织学检查结果在25.7%的受调查病例中呈阳性。大多数为IgA沉积,伴有IgG和C3补体。血尿的强度与组织学改变的类型和严重程度无关。由于这些组织学检查结果,通常被认为正常的“生理性”血尿(红细胞少于7/毫升)必须重新评估。排除泌尿系统或肾外疾病后,只有肾脏的组织学检查才能得出最终诊断。因此可以避免重复进行影像学或泌尿系统检查。在荧光镜或超声控制下进行经皮肾活检的风险明显小于组织学评估所获得的信息。不同的组织学检查结果表明,孤立性血尿应仅被视为一种症状,而不是一种表明局灶性肾炎的统一疾病。