Fielding J W, Hensinger R N, Hawkins R J
J Bone Joint Surg Am. 1980 Apr;62(3):376-83.
A review of the cases of thirty-five patients with os odontoideum, the largest series reported to date, supports the concept that trauma is the etiology of the abnormality. Most of the patients had roentgenographic instability of the affected spinal segment, and were treated with spine fusion. Eleven patients had lesions attributable to injuries received before they were four years old, although surgical treatment usually was delayed for one to eight years. Nine patients had documented roentgenographic evidence of a normal odontoid process prior to the development of the os odontoideum. Only one-third of the patients had any signs or symptoms indicative of neural deficits, although most patients had cervical pain. Surgical treatment alleviated the pain and instability.
对35例齿突骨患者病例的回顾(这是迄今为止报告的最大病例系列)支持了创伤是该异常病因的观点。大多数患者受累脊柱节段存在X线不稳定,并接受了脊柱融合术治疗。11例患者的病变可归因于4岁之前受到的损伤,尽管手术治疗通常延迟1至8年。9例患者在齿突骨形成之前有X线证据证明齿状突正常。只有三分之一的患者有任何神经功能缺损的体征或症状,尽管大多数患者有颈部疼痛。手术治疗缓解了疼痛和不稳定。