Aherne W, Piall E, Marks V
Ann Clin Biochem. 1978 Nov;15(6):331-4. doi: 10.1177/000456327801500179.
75Se-labelled methotrexate has been used as the radiolabel in a radioimmunoassay for methotrexate and its use compared with that of 3H-methotrexate. The gamma-labelled drug has proved to be extremely reliable and easier to use than 3H-methotrexate. Results obtained with it compare well with those obtained with tritiated drug. There are practical advantages in using a gamma emitter, and it is suggested that the modified radioimmunoassay is invaluable for routine monitoring of methotrexate in patients undergoing chemotherapy with the drug.
75硒标记的甲氨蝶呤已被用作甲氨蝶呤放射免疫测定中的放射性标记物，并将其与3H-甲氨蝶呤的使用情况进行了比较。事实证明，这种γ标记药物极其可靠，且比3H-甲氨蝶呤更易于使用。用它获得的结果与用氚标记药物获得的结果相当。使用γ发射体有实际优势，有人认为改进后的放射免疫测定对于接受该药物化疗的患者进行甲氨蝶呤的常规监测非常有价值。
