Howell J B, Freeman R G
J Am Acad Dermatol. 1980 Mar;2(3):224-38. doi: 10.1016/s0190-9622(80)80010-7.
Parallel histopathologic, histochemical, scanning, and transmission electron microscopic (EM) observations were made on palmar pits of one patient and on palmar pits, with an unprecedented number of basal cell carcinomas. of another patient. The first scanning view of tumor growing into the lumen of a pit from the genetically defective epidermis below is presented. The anatomy of the pit is demonstrated for the first time by scanning view of a transected pit. Our observations confirmed those of Hashimoto et al on the mechanisms involved in premature desquamation of the stratum corneum and on the true nature of the epithelium at the base of the pit. This epithelium resembled closely basal cell epithelioma and represented carcinoma in situ. The striking demarcation afforded by the axure B stain of normal and abnormal portions of the palmar epidermis with pit and the poor stainability of the pit with tumor was likewise confirmed. The tumors exhibit aggressive behavior infrequently.
对一名患者的掌跖凹以及另一名患有数量空前的基底细胞癌的患者的掌跖凹进行了平行的组织病理学、组织化学、扫描和透射电子显微镜（EM）观察。呈现了肿瘤从下方基因缺陷的表皮生长到凹坑管腔的首次扫描图像。通过横切凹坑的扫描图像首次展示了凹坑的解剖结构。我们的观察结果证实了桥本等人关于角质层过早脱屑的机制以及凹坑底部上皮的真实性质的观察结果。这种上皮与基底细胞上皮瘤非常相似，代表原位癌。掌跖表皮正常和异常部分（有凹坑）的轴突B染色所提供的明显界限以及有肿瘤的凹坑的染色性差同样得到了证实。这些肿瘤很少表现出侵袭性。
