Omlin F X, Bischoff A, Moor H
J Neuropathol Exp Neurol. 1980 May;39(3):215-31.
In order to investigate the myelin and the glial cell membranes in the optic nerve of the mutant mouse "Jimpy," the method of freeze-etching was applied. The compact myelin lamellae and the first two glial membranes of the mutant, as compared to the normal mouse, show several abnormalities: absence of intramembraneous particles on the P-face, myelin lamellae separated by cytoplasmic layers, vesicular protrusions forming irregular invaginations, and elevations and tight junctions with a discontinuous, zigzag course. Some of these characteristics were found in the membrane of the oligodendroglia cell of the pathological animal, as well. The astrocytic membranes of both normal and Jimpy mice contain two types of gap junctions. The occurrence of one type seems to be increased in the mutant. Freeze-fractured internodal regions of the axolemma are not significantly different from those of normal animals.
为了研究突变小鼠“Jimpy”视神经中的髓磷脂和神经胶质细胞膜，采用了冷冻蚀刻法。与正常小鼠相比，突变小鼠的紧密髓磷脂片层和前两个神经胶质细胞膜显示出几种异常：P面上无膜内颗粒，髓磷脂片层被细胞质层分隔，囊泡状突起形成不规则内陷，以及具有不连续之字形走向的隆起和紧密连接。在患病动物的少突胶质细胞的膜中也发现了其中一些特征。正常小鼠和Jimpy小鼠的星形胶质细胞膜都含有两种类型的缝隙连接。其中一种类型的出现似乎在突变体中有所增加。轴膜的冷冻断裂节间区域与正常动物的没有显著差异。
