去甲替林治疗期间的血浆催乳素水平。

Plasma prolactin during treatment with nortriptyline.

作者信息

Nielsen J L

出版信息

Neuropsychobiology. 1980;6(1):52-5. doi: 10.1159/000117733.

Abstract

The plasma concentrations of prolactin and nortriptyline were determined in 17 patients with endogenous depression treated for 4 weeks with nortriptyline once a day. None of the patients developed galactorrhoea. A moderate but statistically significant increase (about 25%) in the plasma prolactin was found after 3 weeks of treatment. There was no correlation between the plasma levels of prolactin and of nortriptyline. The results indicate that nortriptyline does not belong to the group of psychotropics which produce considerable increases in the plasma concentration of prolactin.

摘要

对17例内因性抑郁症患者进行为期4周的治疗，每日服用一次去甲替林，测定其血浆中催乳素和去甲替林的浓度。所有患者均未出现溢乳现象。治疗3周后，血浆催乳素出现中度但具有统计学意义的升高（约25%）。催乳素与去甲替林的血浆水平之间无相关性。结果表明，去甲替林不属于可使血浆催乳素浓度大幅升高的精神药物类别。