McLean A J, du Souich P, Barron K, Carrier O, Haegele K D, McNay J L
Arch Int Pharmacodyn Ther. 1978 Sep;235(1):19-25.
K+ contractures were induced in paired strips of rabbit aortic smooth muscle. The relationship between relaxant effects and the bath concentration of hydralazine acetone hydrazone (HA), 4-OH-hydralazine (HH) and phthalazine (P) was studied over the concentration range 10(-5)-10(-3)M. All compounds were active, HA = HH greater than P (p less than 0.05; n = 6) at concentrations in the range 10(-4)-10(-3M, HA greater than HH at a concentration of 10(-3M (pgreater than 0.01). The activity of HA did not depend on significant reconversion to hydralazine (H) in the bath ( less than 0.5%). A range of H derivatives may contribute to the hypotensive effects of administered H.
在兔主动脉平滑肌的成对条带上诱导产生钾离子挛缩。研究了在10⁻⁵ - 10⁻³M浓度范围内，肼屈嗪丙酮腙（HA）、4-羟基肼屈嗪（HH）和酞嗪（P）的浴液浓度与舒张作用之间的关系。所有化合物均有活性，在10⁻⁴ - 10⁻³M浓度范围内，HA = HH ＞ P（p ＜ 0.05；n = 6），在10⁻³M浓度时，HA ＞ HH（p＞0.01）。HA的活性并不依赖于其在浴液中显著再转化为肼屈嗪（H）（＜0.5%）。一系列H衍生物可能有助于所给予的H的降压作用。
