Carmon A, Friedman Y, Coger R, Kenton B
Department of Biomedical Engineering, Israel Institute of Technology, Haifa Israel Division of Clinical Neurology, City of Hope National Medical Center, Duarte, Calif. 91010 U.S.A.
Pain. 1980 Feb;8(1):21-32. doi: 10.1016/0304-3959(80)90087-1.
Thermal (laser) evoked responses were obtained from 13 male volunteers. A single trial analysis technique with a latency adjusting adaptive filter was used to analyze evoked response amplitudes. Significant and substantial within-subject linear correlations were found between the magnitude (A) of the primary waveform (RMS muV of the P200--N300-P400 complex ) and subjective pain response (R) as well as stimulus intensity (S). Since subjective pain response was strongly correlated with stimulus intensity, the partial correlation coefficients were calculated for R vs. A with S controlled, and S vs. A with R controlled, for each subject. The partial correlations revealed a much stronger relationship between subjective response and the evoked response amplitude, suggesting that the primary complex may measure neural events in the pain perception process rather than transduction and transmission of the stimulus event.
从13名男性志愿者身上获得了热（激光）诱发反应。采用具有潜伏期调整自适应滤波器的单次试验分析技术来分析诱发反应幅度。在主波形的幅度（A）（P200 - N300 - P400复合波的均方根微伏值）与主观疼痛反应（R）以及刺激强度（S）之间发现了显著且实质性的受试者内线性相关性。由于主观疼痛反应与刺激强度密切相关，因此针对每个受试者计算了在S受控时R与A的偏相关系数以及在R受控时S与A的偏相关系数。偏相关揭示了主观反应与诱发反应幅度之间更强的关系，这表明主复合波可能测量的是疼痛感知过程中的神经事件，而非刺激事件的转导和传递。
