Dumas R, Baldet P, Bascoul S, Serres L, Jean R
Arch Fr Pediatr. 1978 Aug-Sep;35(7):737-55.
Twenty-three children with recurrent macroscopic hematuria have been observed. Six children presented with glomerular disorder with mesangial deposits of IgG and IgA (Berger's disease). The hematuria episodes occurred in the 48 hours following an infection, more often respiratory. Renal functions were not impaired. On light microscopy, glomerular lesions were minimal, or were lesions of focal and segmental glomerulonephritis. Ten children seemed to have hereditary nephritis. In 5 cases, nephritis was accompanied by deafness (Alport's syndrome). In 5, nephritis was hereditary but isolated. The electron microscopy examination of basement membranes showed lesions consistent with Alport's syndrome. In cases of hereditary nephritis without deafness, basement membranes were less impaired. In 7 children, no specific etiology was found.
已观察到23例复发性肉眼血尿患儿。6例患儿表现为肾小球疾病，伴有IgG和IgA系膜沉积（伯杰氏病）。血尿发作发生在感染后的48小时内，更常见于呼吸道感染。肾功能未受损。光镜下，肾小球病变轻微，或为局灶性节段性肾小球肾炎病变。10例患儿似乎患有遗传性肾炎。5例中，肾炎伴有耳聋（阿尔波特综合征）。5例中，肾炎为遗传性但无耳聋。基底膜的电子显微镜检查显示病变与阿尔波特综合征一致。在无耳聋的遗传性肾炎病例中，基底膜受损较轻。7例患儿未发现特定病因。
