大鼠血浆和红细胞中[14C]多胺的清除情况。

Clearance of [14C] polyamines from plasma and erythrocytes in the rat.

作者信息

Wills M R, Shipe J R, Savory J

出版信息

Res Commun Chem Pathol Pharmacol. 1980 Feb;27(2):401-4.

Abstract

The [14C] polyamines, putrescine, spermidine and spermine were administered intravenously to rats. Arterial blood samples were obtained 2, 4, 6, 12, 20, 30, 60 and 120 min. after injection. Plasma and erythrocyte fractions were separated and assayed for [14C] activity. The clearance of radiolabelled polyamines from both the plasma and erythrocytes was rapid. Within 10 min. of injection, plasma putrescine had decreased by 70%, spermine by 80% and spermidine by 85%. In the same time interval the erythrocyte putrescine level had decreased by 50%, spermine by 70% and spermidine by 80%. This data suggests that exogenously injected radiolabelled polyamines and presumably endogenously produced polyamines are rapidly cleared from the circulation.

摘要

将[14C]多胺、腐胺、亚精胺和精胺静脉注射给大鼠。注射后2、4、6、12、20、30、60和120分钟采集动脉血样。分离血浆和红细胞部分并测定[14C]活性。放射性标记多胺从血浆和红细胞中的清除速度都很快。注射后10分钟内，血浆腐胺减少了70%，精胺减少了80%，亚精胺减少了85%。在相同的时间间隔内，红细胞腐胺水平下降了50%，精胺下降了70%，亚精胺下降了80%。该数据表明，外源性注射的放射性标记多胺以及可能内源性产生的多胺会迅速从循环中清除。