Jellinek G
Arkh Patol. 1978;40(11):36-45.
The paper analyses changes in the uterine mucosa caused by the use of hormone drugs, including hormonal contraceptives and studied by light and electron microscopy. Special emphasis is given to changes caused by overdosage of the drugs. Long-term usage of estrogens and progesterone, both separately and particularly in combination, results in marked atrophy and slcerosis of not only uterine mucosa but also of the uterus itself. In women over 35, a long-term oral use of hormonal contraceptives may lead to the development of thromboses and thromboembolias. Therapeutic suggestions are given for different changes of the mucosa revealed by histological studies. A reliable diagnosis should be based on both morphological and functional aspects.
本文分析了使用激素药物（包括激素避孕药）引起的子宫黏膜变化，并通过光学显微镜和电子显微镜进行研究。特别强调了药物过量引起的变化。单独或尤其联合长期使用雌激素和孕激素，不仅会导致子宫黏膜显著萎缩和硬化，还会使子宫本身出现这种情况。对于35岁以上的女性，长期口服激素避孕药可能会导致血栓形成和血栓栓塞。针对组织学研究揭示的黏膜不同变化给出了治疗建议。可靠的诊断应基于形态学和功能方面。
