家兔体内甲基麦角新碱（甲基麦角新碱）的血浆和组织浓度。

Plasma and tissue concentrations of methylergometrine (methylergonovine) in the rabbit.

作者信息

Mäntylä R, Kanto J, Kleimola T, Seppälä M

出版信息

Acta Pharmacol Toxicol (Copenh). 1980 Apr;46(4):245-9. doi: 10.1111/j.1600-0773.1980.tb02449.x.

DOI:10.1111/j.1600-0773.1980.tb02449.x

Abstract

The concentrations of methylergometrine (M) (methylergonovine) in the plasma, uterus, liver, and kidneys of the rabbit were determined by a radioimmunoassay after a single 0.2 mg/kg intravenous injection and the drug response was studied in the uterus in situ. M disappeared quickly from the plasma with a mean distribution phase half-life of 0.91 min. According to the fast uterine tissue uptake of M the drug response in this effector organ began quickly. The stimulated concentrations in the peripheral compartment of the two-compartment open model can be useful in the understanding of the rapid drug effect, but they do not describe the real situation in any particular tissue.

摘要

单次静脉注射0.2mg/kg甲基麦角新碱（M）（甲基麦角新碱）后，采用放射免疫分析法测定了家兔血浆、子宫、肝脏和肾脏中甲基麦角新碱的浓度，并对原位子宫的药物反应进行了研究。M从血浆中迅速消失，平均分布相半衰期为0.91分钟。根据M对子宫组织的快速摄取，该效应器官中的药物反应迅速开始。二室开放模型外周室中的刺激浓度有助于理解药物的快速作用，但它们并不能描述任何特定组织中的实际情况。