可逆性骨髓肉芽肿——羟基保泰松治疗的不良反应
Reversible bone marrow granulomas-adverse effect of oxyphenbutazone therapy.
作者信息
Andersson D E, Langworth S, Newman H C, Ost A
出版信息
Acta Med Scand. 1980;207(1-2):131-3. doi: 10.1111/j.0954-6820.1980.tb09691.x.
Abstract
A 48-year-old woman treated with oxyphenbutazone developed fever, gastrointestinal disturbances, mucocutaneous reactions, leukopenia, eosinophilia and thrombocytopenia. Bone marrow biopsy showed granulomatous lesions. Following withdrawal of the drug, all signs and symptoms subsided and the blood changes and the bone marrow biopsy normalized. The granulomatous reaction in the bone marrow is considered to be a hypersensitivity manifestation of oxyphenbutazone.
摘要
一名48岁女性在使用羟基保泰松治疗后出现发热、胃肠道紊乱、黏膜皮肤反应、白细胞减少、嗜酸性粒细胞增多和血小板减少。骨髓活检显示肉芽肿性病变。停药后，所有体征和症状均消退，血液变化及骨髓活检结果恢复正常。骨髓中的肉芽肿反应被认为是羟基保泰松的一种超敏反应表现。
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