Furosemide-induced renal vasodilation: the role of the release of arachidonic acid.

Furosemide administration results in an increase in blood flow through the prostaglandin system by causing the release of arachidonic acid from a small pool of lipid stores from the kidney without affecting the total arachidonic acid concentration in the blood. The stimulus for arachidonic acid release from the kidney depends on an intrarenal mechanism whereby the diuresis is coupled to the increase in renal blood flow.