Contribution of urine volume to the elevated urinary prostaglandin E in Bartter's syndrome and central and nephrogenic diabetes insipidus.

1. Urinary PGE is elevated above normal in patients with Bartter's syndrome, central and nephrogenic diabetes insipidus. 2. K+ loading, Mg2+ infusion, and water-loading-all of which increased urine volume-were associated with augmented urinary PGE in Bartter's syndrome, while fluid restriction decreased urinary PGE to normal. 3. Antidiuresis in central diabetes insipidus with DDAVP, and with indomethacin or ibuprofen in nephrogenic diabetes insipidus, is associated with a decrease in urinary PGE. 4. High urine volume may be a contributing factor to the elevated urinary PGE in Bartter's syndrome, central and nephrogenic diabetes insipidus.