Stothert J C
Ann Surg. 1980 Apr;191(4):456-9. doi: 10.1097/00000658-198004000-00011.
Previous reports suggest the value of renal decapsulation in the prevention of renal failure after acute ischemia. It has been suggested that this response is due to a release of "compartmental" pressure resulting in increased blood flow to the decapsulated kidney. Ten dogs were evaluated following 90 minutes of renal ischemia created by occlusion of the suprarenal aorta. Each animal underwent random unilateral decapsulation, with the contralateral kidney acting as control. Labeled 15 micron microspheres (Se85 and Ce141) were injected into the left ventricle at 15 minutes and one hour following decapsulation in six dogs. In the remaining animals the injection was carried out at 15 minutes and 48 hours. No difference in renal blood flow was found between decapsulated and control kidneys in either group. Similarly, using sectioned kidneys no difference in intrarenal distribution of blood flow was found. These data suggest that the effects caused by decapsulation are not due to hemodynamic alterations.
先前的报告表明肾被膜剥除术在预防急性缺血后肾衰竭方面的价值。有人认为这种反应是由于“隔室”压力的释放，导致流向被剥除肾被膜的肾脏的血流量增加。通过阻断肾上腺上方的主动脉造成90分钟肾缺血后，对10只狗进行了评估。每只动物随机进行单侧被膜剥除术，对侧肾脏作为对照。在6只狗被膜剥除后的15分钟和1小时，将标记的15微米微球（硒85和铈141）注入左心室。在其余动物中，在15分钟和48小时进行注射。两组中，被剥除肾被膜的肾脏和对照肾脏之间的肾血流量均未发现差异。同样，对切开的肾脏进行检查，也未发现肾内血流分布有差异。这些数据表明，被膜剥除术所产生的效果并非由于血流动力学改变所致。
