Vogel E
Arch Toxicol. 1980 Jan;43(3):201-11. doi: 10.1007/BF00297585.
Two Drosophila populations, one resistant and the other susceptible to several insecticides, were examined for response to several alkaryltriazenes (2,4,6-Cl3-PDMT; 3-PyDMT; 3-PyDET) and to DMN, DEN and AM. Hikone R (HR) males developed relative resistance to both mutation induction and cell killing by the triazenes, whereas Berlin K (BK) males showed increased tolerance to DMN, DEN, and AM. When F1 hybrid males from the two strains were treated with 2,4,6-Cl3-PDMT, the yield of recessive lethal mutations in the heterozygotes was nearly half of that found in homozygotes from the susceptible strain Berlin K. These findings indicate that in Drosophila metabolism of procarcinogens is controlled by multiple-gene systems located on several chromosomes. An extremely divergent response of the two genotypes was found following treatment with 3-PyDET; this triazene acts as a potent mutagen in BK males but is hardly mutagenic when tested in strain HR.
对两个果蝇种群进行了检测，一个种群对几种杀虫剂具有抗性，另一个种群对几种杀虫剂敏感，检测它们对几种烷基三氮烯（2,4,6-三氯-PDMT；3-吡啶基-DMT；3-吡啶基-DET）以及对二甲基亚硝胺（DMN）、二乙基亚硝胺（DEN）和丙烯酰胺（AM）的反应。彦根R（HR）品系的雄蝇对三氮烯诱导突变和细胞杀伤产生了相对抗性，而柏林K（BK）品系的雄蝇对DMN、DEN和AM表现出更高的耐受性。当用2,4,6-三氯-PDMT处理来自这两个品系的F1杂交雄蝇时，杂合子中隐性致死突变的发生率几乎是敏感品系柏林K纯合子中发现的发生率的一半。这些发现表明，在果蝇中，前致癌物的代谢受位于几条染色体上的多基因系统控制。在用3-吡啶基-DET处理后，发现这两种基因型的反应极为不同；这种三氮烯在BK品系雄蝇中是一种强效诱变剂，但在HR品系中进行测试时几乎没有诱变作用。
