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The inhibition of dihydrofolate reductase by folate analogues: structural requirements for slow- and tight-binding inhibition.

作者信息

Williams J W, Duggleby R G, Cutler R, Morrison J F

出版信息

Biochem Pharmacol. 1980 Feb 15;29(4):589-95. doi: 10.1016/0006-2952(80)90381-0.

DOI:10.1016/0006-2952(80)90381-0
PMID:7370052
Abstract
摘要

相似文献

1
The inhibition of dihydrofolate reductase by folate analogues: structural requirements for slow- and tight-binding inhibition.
Biochem Pharmacol. 1980 Feb 15;29(4):589-95. doi: 10.1016/0006-2952(80)90381-0.
2
Two different effects of mutation on the binding of folate antagonists by a microbial dihydrofolate reductase.突变对微生物二氢叶酸还原酶结合叶酸拮抗剂的两种不同影响。
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Inhibition of dihydrofolate reductase from bacterial and vertebrate sources by folate, aminopterin, methotrexate and their 5-deaza analogues.叶酸、氨基蝶呤、甲氨蝶呤及其5-脱氮类似物对细菌和脊椎动物来源的二氢叶酸还原酶的抑制作用。
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4
Mechanism of inhibition of dihydrofolate reductases from bacterial and vertebrate sources by various classes of folate analogues.各类叶酸类似物对细菌和脊椎动物来源的二氢叶酸还原酶的抑制机制。
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Folate analogues. 20. Synthesis and antifolate activity of 1',2',3',4',5',6'-hexahydrohomofolic acid.
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6
Molecular basis for the interaction of polyglutamates of folic acid and its analogs with dihydrofolate reductase.叶酸及其类似物的聚谷氨酸与二氢叶酸还原酶相互作用的分子基础。
Adv Exp Med Biol. 1983;163:1-18. doi: 10.1007/978-1-4757-5241-0_1.
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Human dihydrofolate reductase: reduction of alternative substrates, pH effects, and inhibition by deazafolates.人二氢叶酸还原酶：替代底物的还原、pH值影响及脱氮叶酸的抑制作用
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8
Dihydrofolate reductase: the current story.
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9
Effect of 11-oxahomofolate and its reduced derivatives on human dihydrofolate reductase and on human cells having different amounts of dihydrofolate reductase.
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Folate analogues altered in the C9-N10 bridge region: N10-Toxylisohomofolic acid and N10-Toxylisohomoaminopterin.在C9-N10桥区域发生改变的叶酸类似物：N10-毒氧异高叶酸和N10-毒氧异高氨蝶呤。
J Med Chem. 1978 Jul;21(7):673-7. doi: 10.1021/jm00205a015.

引用本文的文献

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Chemical space of Escherichia coli dihydrofolate reductase inhibitors: New approaches for discovering novel drugs for old bugs.大肠杆菌二氢叶酸还原酶抑制剂的化学空间：发现新型老菌药物的新方法。
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Poly(amidoamine) dendrimer-methotrexate conjugates: the mechanism of interaction with folate binding protein.聚（酰胺胺）树枝状大分子-甲氨蝶呤偶联物：与叶酸结合蛋白的相互作用机制
Mol Pharm. 2014 Nov 3;11(11):4049-58. doi: 10.1021/mp500608s. Epub 2014 Oct 1.
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Avidity mechanism of dendrimer-folic acid conjugates.
树枝状聚合物-叶酸共轭物的亲合力机制。
Mol Pharm. 2014 May 5;11(5):1696-706. doi: 10.1021/mp5000967. Epub 2014 Apr 11.
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Self-assembly of antibodies by chemical induction.通过化学诱导实现抗体的自组装。
Angew Chem Int Ed Engl. 2008;47(52):10179-82. doi: 10.1002/anie.200803507.
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Kinetic and e.p.r. studies on the inhibition of xanthine oxidase by alloxanthine (1 H-pyrazolo [3, 4-d] pyrimidine-4,6-diol).关于别嘌呤醇（1H-吡唑并[3,4-d]嘧啶-4,6-二醇）对黄嘌呤氧化酶抑制作用的动力学和电子顺磁共振研究。
Biochem J. 1981 Jun 1;195(3):753-60. doi: 10.1042/bj1950753.
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Synthesis of lysine-containing sulphonium salts and their properties as proteinase inhibitors.含赖氨酸的锍盐的合成及其作为蛋白酶抑制剂的性质。
Biochem J. 1988 Mar 15;250(3):871-6. doi: 10.1042/bj2500871.
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Progress-curve equations for reversible enzyme-catalysed reactions inhibited by tight-binding inhibitors.被紧密结合抑制剂抑制的可逆酶催化反应的进程曲线方程。
Biochem J. 1990 Feb 1;265(3):647-53. doi: 10.1042/bj2650647.