[Sulpiride and renal action of dopamine in hydro-saline depletion in humans].

The effect of sulpiride (racemic form) pretreatment on renal action of dopamine (DA) has been investigated in 8 hydro-saline depleted human subjects. Two studies were carried out in the presence and in the absence of sulpiride, respectively. DA was infused in a subpressor dose (0,1 microgram.kg-1 . min-1) during induced hypotonic polyuria. The experimental results suggest that tubular DA effects are enhanced whilst glomerular DA effects are reversed by the presence of sulpiride.