Chelazzi G, Verna E, Mandelli Contegni G M, Rossi D, Sala G
Biomedicine. 1980 Feb;32(1):21-5.
Measurement of the size of marrow granulocyte reserve (MGR) was performed in ten alcoholic patients with clinically uncomplicated Laennec's cirrhosis and in ten healthy subjects by etiocholanolone injection before and during oral 95% ethyl alcohol administration (30 to 60 ml in orange juice every 6 hours for 48 hours). No significant differences in bone marrow response to etiocholanolone were found between normal subjects studied before and during alcohol administration. The group of cirrhotic patients failed to demonstrate a reduction of MGR when compared to control subjects and alcohol administration did not result in an abnormal response to etiocholanolone. It is suggested that the MGR is normal in most alcoholic patients with clinically uncomplicated Laennec's cirrhosis and is not influenced by acute alcohol ingestion. These results are in contrast to other previous reports in which bacterial endotoxin was used to estimate granulocyte reserve.
通过在口服95%乙醇（每6小时30至60毫升橙汁混合液，共48小时）前后注射本胆烷醇酮，对10例临床无并发症的Laennec肝硬化酒精性患者和10名健康受试者进行了骨髓粒细胞储备（MGR）大小的测量。在酒精给药前和给药期间研究的正常受试者之间，未发现骨髓对本胆烷醇酮反应的显著差异。与对照受试者相比，肝硬化患者组未表现出MGR降低，并且酒精给药未导致对本胆烷醇酮的异常反应。提示大多数临床无并发症的Laennec肝硬化酒精性患者的MGR正常，且不受急性酒精摄入的影响。这些结果与之前其他使用细菌内毒素估计粒细胞储备的报告相反。
