恶性神经鞘瘤：光镜和超微结构研究

Malignant schwannoma: a light microscopic and ultrastructural study.

作者信息

Chen K T, Latorraca R, Fabich D, Padgug A, Hafez G R, Gilbert E F

出版信息

Cancer. 1980 Apr 1;45(7):1585-93. doi: 10.1002/1097-0142(19800401)45:7<1585::aid-cncr2820450712>3.0.co;2-p.

DOI:10.1002/1097-0142(19800401)45:7<1585::aid-cncr2820450712>3.0.co;2-p

Abstract

The light microscopic and ultrastructural features of 3 cases of malignant schwannoma were studied and compared with those of other types of soft-tissue sarcoma. The tumor in 1 of these cases originated in an intercostal nerve and was composed of compactly arranged spindle-shaped tumor cells. The other 2 cases showed osteogenic areas in addition to exhibiting prominent nuclear palisading, focal myxoid changes, and a rosette-like arrangement of tumor cells. The tumor in 1 of these latter cases occurred at the site of a preexisting neurofibroma. The Schwann cell origin of these tumors is strongly supported by the ultrastructural findings of basement membranes and conspicuous intercellular junctions in all 3 cases and dense-core granules in 1.

摘要

对3例恶性神经鞘瘤的光镜和超微结构特征进行了研究，并与其他类型的软组织肉瘤进行了比较。其中1例肿瘤起源于肋间神经，由紧密排列的梭形肿瘤细胞组成。另外2例除了有明显的核栅栏状排列、局灶性黏液样改变和肿瘤细胞呈玫瑰花结样排列外，还显示有成骨区域。后2例中的1例肿瘤发生在先前存在的神经纤维瘤部位。所有3例肿瘤的超微结构发现有基底膜和明显的细胞间连接，1例有致密核心颗粒，有力地支持了这些肿瘤起源于施万细胞。