替克瑞纳芬在无肾患者中的应用：对尿酸及药代动力学的影响。

Ticrynafen in anephric patients: effects on uric acid and pharmacokinetics.

作者信息

Murray T G, Brown S, Dubb J W, Hwang B Y, Stote R M

出版信息

Clin Pharmacol Ther. 1980 May;27(5):686-9. doi: 10.1038/clpt.1980.97.

DOI:10.1038/clpt.1980.97

Abstract

Ticrynafen was given to 6 anephric patients undergoing maintenance hemodialysis. Ticrynafen was given daily for the 3 days between hemodialyses. Ticrynafen had no effect on the interdialysis rise in serum uric acid levels. Ticrynafen did not accumulate in serum, but levels of metabolites continued to rise over the 3 days. Hemodialysis (5 hr) reduced levels of ticrynafen by 38% but had less effect on metabolite levels. There was no effect on serum cholesterol or triglycerides.

摘要

将替克瑞纳芬给予6名接受维持性血液透析的无肾患者。在血液透析期间的3天里，每天给予替克瑞纳芬。替克瑞纳芬对透析间期血清尿酸水平的升高没有影响。替克瑞纳芬不会在血清中蓄积，但代谢产物的水平在3天内持续升高。血液透析（5小时）使替克瑞纳芬的水平降低了38%，但对代谢产物水平的影响较小。对血清胆固醇或甘油三酯没有影响。