哈尔明对豚鼠心房肌动作电位持续时间影响的频率依赖性
Frequency dependence of the effect of harmine on the duration of the action potential of guinea pig atrial muscle.
作者信息
Carpentier R G
出版信息
Eur J Pharmacol. 1980 Apr 4;62(4):341-4. doi: 10.1016/0014-2999(80)90102-8.
PMID:7371728
Abstract
The effect of harmine on the duration of the action potential (APD) of guinea pig atrial muscle is analyzed. Harmine prolongs APD through both a depressant effect on automaticity and a direct effect on atrial repolarization. In atria driven at a constant rate: (a) the direct effect becomes less with a faster drive; (b) an increase in concentration of harmine does not result in a greater prolongation of APD. Increased extracellular Ca2+ concentration annulles the APD-prolonging effect.
摘要
分析了哈尔明对豚鼠心房肌动作电位（APD）时程的影响。哈尔明通过对自律性的抑制作用和对心房复极化的直接作用来延长APD。在以恒定速率驱动的心房中：（a）驱动速度越快，直接作用越小；（b）哈尔明浓度增加不会导致APD延长更多。细胞外Ca2+浓度升高可消除APD延长效应。
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引用本文的文献
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The effect of harmine on the action potential of the guinea-pig atrial muscle depends on the external calcium concentration.骆驼蓬碱对豚鼠心房肌动作电位的影响取决于细胞外钙浓度。
Br J Pharmacol. 1981 Oct;74(2):415-8. doi: 10.1111/j.1476-5381.1981.tb09986.x.
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